个人简介

吴介恒，中共党员，副教授，医学博士，博士后，免疫学博士研究生导师。现任贵州医科大学基础医学院免疫学教研室副教授，全国高校“黄大年式教学团队”成员，中国免疫学会青年工作委员会委员，贵州省免疫学会理事，国家自然科学基金通讯评审专家，贵州省科技厅专家库专家，贵阳市口腔医院院外特聘专家，多本SCI杂志（Journal of Cellular and Molecular Medicine, Medical Science Monitor，Frontiers系列）审稿专家，主要从事肿瘤免疫与肿瘤微环境研究。主持国家自然科学基金项目2项，贵州省科技厅基础研究计划项目1项，校级项目4项；参与国家自然科学基金重点项目1项；发表SCI论文18篇，获实用新型专利3项，参编专著1部，参编教材1部。

主要研究方向

(1)肿瘤微环境调控机制

(2)肿瘤免疫

近年来发表文章

[1]Jiangwei Wu, Qiaoling Zhang, Zeyang Yang, Yujun Xu, Xinlei Liu, Xuanying Wang, Jiangying Peng, Jing Xiao, Yun Wang, Zhenling Shang, Nianxue Wang, Long Li, Rui Zhang, Wei Zhang*, Jian Zhang*, Zhu Zeng*, Jieheng Wu*; CD248-expressing cancer-associated fibroblasts induce non-small cell lung cancer metastasis via Hippo pathway-mediated extracellular matrix stiffness, Journal of Cellular and Molecular Medicine, 2024，28（16）：e70025.（通讯作者，5年平均影响因子：5.3）

[2]Jing Xiao, Zeyang Yang, Siyu Wang, Xinlei Liu, Yun Wang, Zuquan Hu, Zhu Zeng*, Jieheng Wu*; CD248‑expressing cancer‑associated fibroblasts induce epithelial–mesenchymal transition of non‑small cell lung cancer via inducing M2‑polarized macrophages, Scientific Reports, 2024,14(1):14343. （通讯作者，5年平均影响因子：5.3）

[3]Jieheng Wu #*，Qiaoling Zhang#， Jiangwei Wu#，Zeyang Yang#，Xinlei Liu#，Chunju Lou， Xuanyin Wang，Jiangying Peng，Jinyuan Zhang，Zhenling Shang，Jing Xiao，Nianxue Wang，Ruya Zhang，Jinyao Zhou，Yun Wang，Zuquan Hu，Rui Zhang，Jian Zhang*，Zhu Zeng*；IL-8 from CD248-expressing cancer-associated fibroblasts generates cisplatin resistance in non-small cell lung cancer，Journal of Cellular and Molecular Medicine, 2024,28(4):18185. （第一作者/通讯作者，5年平均影响因子：5.3）

[4]Jieheng Wu #*; Xinlei Liu#; Jiangwei Wu#; Chunju Lou#; Qiaoling Zhang; Huiping Chen; Zeyang Yang; Shiqi Long; Yun Wang; Zhenling Shang; Zuquan Hu; Rui Zhang; Jian Zhang*; Zhu Zeng*; CXCL12 derived from CD248-expressing cancer-associated fibroblasts mediates M2-polarized macrophages to promote nonsmall cell lung cancer progression, Biochim Biophys Acta Mol Basis Dis, 2022,1868(11): 166521.（第一作者/通讯作者，5年平均影响因子：6.919）

[5]Jieheng Wu #; Donghui Han#; Shengjia Shi#; Qiang Zhang; Guoxu Zheng; Ming Wei; Yueheng Han;Guodong Li; Fa Yang; Dian Jiao; Pin Xie; Lingling Zhang; An-Gang Yang; Aizhi Zhao; Weijun Qin;Weihong Wen ; A Novel Fully Human Antibody targeting Extracellular Domain of PSMA Inhibits TumorGrowth in Prostate Cancer, Molecular Cancer Therapeutics, 2019, 18(7): 1289-1301. （第一作者，5年平均影响因子：7.06）

[6]Fa Yang#; Yan Wei#; Donghui Han#; Yu Li; Shengjia Shi; Dian Jiao; Jieheng Wu; Qiang Zhang; Changhong Shi; Lijun Yang; Wei Song; Jingliang Zhang; Yueheng Han; Rui Zhang; An-Gang Yang; Dimiter S. Dimitrov; Aizhi Zhao; Weijun Qin*; Weihong Wen*; Interaction with CD68 and Regulation of GAS6 Expression by Endosialin in Fibroblasts Drives Recruitment and Polarization of Macrophages in Hepatocellular Carcinoma, Cancer Research, 2020, 80(18): 3892-3905. （5年平均影响因子：13.678）

[7]Sheng-Jia Shi #; Li-Juan Wang #; Dong-Hui Han #; Jie-Heng Wu#; Dian Jiao; Kai-Liang Zhang;Jiang-Wei Chen; Yu Li; Fa Yang; Jing-Liang Zhang; Guo-Xu Zheng; An-Gang Yang; Ai-Zhi Zhao; Wei-Jun Qin; Wei-Hong Wen ; Therapeutic effects of human monoclonal PSMA antibody-mediated TRIM24 siRNA delivery in PSMA-positive castration-resistant prostate cancer, Theranostics, 2019, 9(5):1247—1263. （共同第一作者，5年平均影响因子：12.201）

[8]Dian Jiao #; Yi Huan #; Jia Zheng; Ming Wei; Guoxu Zheng; Donghui Han; Jieheng Wu; Wenjin Xi; Feilong Wei; An-Gang Yang; Weijun Qin*; He Wang*; Weihong Wen*; UHRF1 promotes renal cell carcinoma progression through epigenetic regulation of TXNIP, Oncogene, 2019, 38(28): 5686-5699. （5年平均影响因子：9.273）

[9]Donghui Han#, Jieheng Wu#, Yueheng Han, Ming Wei, Sen Han, Ruihe Lin, Ziyong Sun, Fa Yang, Dian Jiao, Pin Xie, Lingling Zhang, An-Gang Yang, Aizhi Zhao*, Weihong Wen*, Weijun Qin*. A novel anti-PSMA human scFv has the potential to be used as a diagnostic tool in prostate cancer, Oncotarget, 2016, 7(37):59471-59481. （共同第一作者，影响因子：5.008）

[10]Qi Li#, Jieheng Wu#, Wenjin Xi, Xu Chen, Wei Wang, Tianze Zhang, Angang Yang, Tao Wang. Ctrp4, a new adipokine, promotes the differentiation of osteoblasts, Biochem Biophys Res Commun, 2019,512(2):224-229.（共同第一作者，5年平均影响因子：3.2）

[11]Dian Jiao, Yu Li, Fa Yang, Donghui Han, Jieheng Wu, Shengjia Shi, Feng Tian, Zhangyan Guo, Wenjin Xi, Guodong Li, Aizhi Zhao, An-Gang Yang, Weijun Qin, He Wang*, Weihong Wen*. Expression of Prostate-Specific Membrane Antigen in Tumor-Associated Vasculature Predicts Poor Prognosis in Hepatocellular Carcinoma, Clin Transl Gastroenterol, 2019,10(5):1-7.（5年平均影响因子：4.3）

(1)国家自然科学基金委员会, 地区科学基金项目, 82160566, 2022-01-01 至 2025-12-31, 34万元,主持

(2)国家自然科学基金委员会, 地区科学基金项目, 82460533, 2025-01-01 至 2028-12-31, 32万元,主持